Phospho-mTOR (S2448) Antibody

Rabbit mAb

Western blot analysis of Phospho-mTOR (S2448) expression in HEK293 cell lysate.
Immunohistochemical analysis of paraffin-embedded human breast cancer, using Phospho-mTOR (S2448) Antibody.
Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy. -Cellular Physiology and Biochemistry
Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy. -Cellular Physiology and Biochemistry
Overexpression of the 14-3-3γ protein in uterine leiomyoma cells results in growth retardation and increased apoptosis. -Cellular Signalling
A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II. -EXPERIMENTAL AND MOLECULAR MEDICINE

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC
Primary Accession	P42345
Reactivity	Rat, Pig, Human, Mouse
Clonality	Monoclonal
Other Names	FRAP; FRAP1; FRAP2; RAFT1; Rapamycin target protein; kinase mTOR;
Isotype	Rabbit IgG
Host	Rabbit
Calculated MW	289 KDa

Additional Information
Dilution	WB 1:500~1:1000 IHC 1:50~1:100
Purification	Affinity-chromatography
Immunogen	A synthesized peptide derived from human Phospho-mTOR (S2448)
Description	An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.
Storage Condition and Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.