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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   EpCAM Antibody   

EpCAM Antibody

Rabbit mAb

     
  • 1 - EpCAM Antibody AP90759
    Western blot analysis of EpCAM expression in A431 cell lysate.
  • 2 - EpCAM Antibody AP90759
    Immunohistochemical analysis of paraffin-embedded human stomach carcinoma, using EpCAM Antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession P16422
Reactivity Human
Clonality Monoclonal
Other Names Epithelial cell adhesion molecule; Ep-CAM; CO17A; CD326; Cell surface glycoprotein Trop-1; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 34932 Da
Additional Information
Dilution WB 1:1000~1:2000 IHC 1:50~1:200
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human EpCAM
Description Epithelial cell adhesion and activating molecule (EpCAM/CD326) is a transmembrane glycoprotein that mediates Ca2+ independent, homophilic adhesions on the basolateral surface of most epithelial cells. The antigen is being used as a target for immunotherapy treatment of human carcinomas.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name EPCAM
Synonyms GA733-2, M1S2, M4S1, MIC18, TACSTD1, TRO
Function May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Cellular Location Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction
Tissue Location Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC) Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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