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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   Alpha Synuclein Antibody   

Alpha Synuclein Antibody

Rabbit mAb

     
  • 1 - Alpha Synuclein Antibody AP90187
    Western blot analysis of Alpha Synuclein expression in Human fetal brain lysate.
  • 2 - Alpha Synuclein Antibody AP90187
    Immunohistochemical analysis of paraffin-embedded mouse testis, using Alpha Synuclein Antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, IF, FC, ICC, IP, IHF
Primary Accession P37840
Reactivity Human
Clonality Monoclonal
Other Names Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; PARK1; PARK4; PD1; SNCA;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 14460 Da
Additional Information
Dilution WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human Alpha Synuclein
Description May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies).
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name SNCA
Synonyms NACP, PARK1
Function Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).
Cellular Location Cytoplasm. Membrane Nucleus Synapse. Secreted. Cell projection, axon {ECO:0000250|UniProtKB:O55042}. Note=Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:O55042, ECO:0000269|PubMed:15282274}
Tissue Location Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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