癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Guanylyl Cyclase beta 1 (GUCY1B3) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q02153 |
| Other Accession | NP_000848 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70514 Da |
| Antigen Region | 589-619 aa |
| Gene ID | 2983 |
|---|---|
| Other Names | Guanylate cyclase soluble subunit beta-1, GCS-beta-1, Guanylate cyclase soluble subunit beta-3, GCS-beta-3, Soluble guanylate cyclase small subunit, GUCY1B3, GUC1B3, GUCSB3, GUCY1B1 |
| Target/Specificity | This GUCY1B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected between 589-619 amino acids of human GUCY1B3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Guanylyl Cyclase beta 1 (GUCY1B3) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GUCY1B1 (HGNC:4687) |
|---|---|
| Function | Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P16068}. |
| Tissue Location | Detected in brain cortex and cerebellum (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
REFERENCES
Russwurm, M., et al., J. Biol. Chem. 276(48):44647-44652 (2001).
Lucas, K.A., et al., Pharmacol. Rev. 52(3):375-414 (2000).
Papapetropoulos, A., et al., J. Cell. Physiol. 167(2):213-221 (1996).
Giuili, G., et al., Hum. Genet. 91(3):257-260 (1993).
Giuili, G., et al., FEBS Lett. 304(1):83-88 (1992).
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