癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FKBP1B Antibody (N-term E6)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P68106 |
| Other Accession | P97534, Q8HYX6, Q9Z2I2, P68107, P62943, P26883, P62942, P18203 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rabbit, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 11783 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 2281 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 126 kDa FK506-binding protein, 126 kDa FKBP, FKBP-126, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP126, Rotamase, h-FKBP-12, FKBP1B, FKBP126, FKBP1L, FKBP9, OTK4 |
| Target/Specificity | This FKBP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FKBP1B. |
| Dilution | WB~~1:1000 IF~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FKBP1B Antibody (N-term E6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FKBP1B (HGNC:3712) |
|---|---|
| Function | Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| Cellular Location | Cytoplasm. Sarcoplasmic reticulum |
| Tissue Location | Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FKBP1B is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. The protein is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle.
REFERENCES
Arakawa H., Nagase H.Biochem. Biophys. Res. Commun. 200:836-843(1994)
Lam E., Martin M.M., Timerman A.P.Biol. Chem. 270:26511-26522(1995)
Deivanayagam C.C., Carson M.Acta Crystallogr. D 56:266-271(2000)
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