BCAR1 Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	P56945
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	93372 Da

Additional Information
Gene ID	9564
Other Names	BCAR1
Dilution	WB~~1/500-1/1000
Format	10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Protein Information
Name	BCAR1
Synonyms	CAS, CASS1, CRKAS
Function	Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).
Cellular Location	Cell junction, focal adhesion. Cytoplasm Cell projection, axon {ECO:0000250\|UniProtKB:Q61140} Note=Unphosphorylated form localizes in the cytoplasm (By similarity) Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250\|UniProtKB:Q61140}
Tissue Location	Expressed in B-cells (at protein level) (PubMed:9020138). Widely expressed with an abundant expression in the testis (PubMed:10639512). Low level of expression seen in the liver, thymus, and peripheral blood leukocytes (PubMed:10639512)