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>   首页   >   产品   >   一抗   >   癌症   >   IGFBP3 Antibody (S183)   

IGFBP3 Antibody (S183)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - IGFBP3 Antibody (S183) AP7641D
    Anti-IGFBP-3-S183 Antibody at 1:1000 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 32 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P17936
Other Accession P16611, P20959
Reactivity Human, Hamster, Rat, Mouse
Predicted Pig, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 31674 Da
Antigen Region 162-189 aa
Additional Information
Gene ID 3486
Other Names Insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3, IGFBP3, IBP3
Target/Specificity This IGFBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-189 amino acids from human IGFBP3.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGFBP3 Antibody (S183) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGFBP3
Synonyms IBP3
Function Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:10874028, PubMed:19556345). Also exhibits IGF- independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R (PubMed:20353938). Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275). Acts via LRP- 1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1 (PubMed:9252371). Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade (PubMed:15371331). In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis (PubMed:10874028).
Cellular Location Secreted. Nucleus
Tissue Location Expressed by most tissues. Present in plasma.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family with an IGFBP domain and a thyroglobulin type-I domain. This protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

REFERENCES

Muzumdar,R.H., Diabetes 55 (10), 2788-2796 (2006) Novosyadlyy,R., Growth Horm. IGF Res. 15 (5), 313-323 (2005)

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