TXNRD2 Rabbit mAb

Western blot analysis of TXNRD2 in mouse heart lysates using Thioredoxin Reductase 2 antibody.
Western blot analysis of TXNRD2 in K562, Hela lysates using TXNRD2 antibody.
Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using TXNRD2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	Q9NNW7
Reactivity	Rat, Human, Mouse
Host	Rabbit
Clonality	Monoclonal Antibody
Isotype	IgG
Conjugate	Unconjugated
Purification	Affinity Purified
Calculated MW	56507 Da

Additional Information
Gene ID	10587
Other Names	TXNRD2
Dilution	WB~~1:1000-1:5000 IHC-P~~1:50~200
Format	Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Protein Information
Name	TXNRD2 (HGNC:18155)
Synonyms	KIAA1652, TRXR2
Function	Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox- regulated cell signaling.
Cellular Location	Mitochondrion.
Tissue Location	Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690).