癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HSD17B7 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P56937 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38206 Da |
| Antigen Region | 57-85 aa |
| Gene ID | 51478 |
|---|---|
| Other Names | 3-keto-steroid reductase, 17-beta-hydroxysteroid dehydrogenase 7, 17-beta-HSD 7, Estradiol 17-beta-dehydrogenase 7, HSD17B7 |
| Target/Specificity | This HSD17B7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 amino acids from the N-terminal region of human HSD17B7. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HSD17B7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HSD17B7 |
|---|---|
| Synonyms | 17HSD7 {ECO:0000303|PubMed:12732193}, SD |
| Function | Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:11165030, PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:19772289, PubMed:20659585). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts dihydrotestosterone (DHT) to its inactive form 5a-androstane-3b,17b- diol (PubMed:12574203, PubMed:12732193, PubMed:19772289). Converts moderately progesterone to 3beta-hydroxypregn-4-ene-20-one, leading to its inactivation (PubMed:12574203, PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3- ketosteroid reductase (PubMed:11165030, PubMed:12829805, PubMed:20659585). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
| Tissue Location | Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea Weakly expressed in all other tissues tested |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
HSD17B7 oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.
REFERENCES
Plourde,M., et.al.,J. Steroid Biochem. Mol. Biol. 116 (3-5), 134-153 (2009)
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