癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Synphilin-1 (SNCAIP) Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y6H5 |
| Other Accession | NP_005451 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 100409 Da |
| Antigen Region | 593-622 aa |
| Gene ID | 9627 |
|---|---|
| Other Names | Synphilin-1, Sph1, Alpha-synuclein-interacting protein, SNCAIP |
| Target/Specificity | This Synphilin-1 (SNCAIP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-622 amino acids from the C-terminal region of human Synphilin-1 (SNCAIP). |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Synphilin-1 (SNCAIP) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNCAIP |
|---|---|
| Function | Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. |
| Cellular Location | Cytoplasm. Note=Detected in cytoplasmic inclusion bodies, together with SNCA |
| Tissue Location | Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease
REFERENCES
Kruger,R. Cell Tissue Res. 318 (1), 195-199 (2004)
Lee,G., etal. J. Biol. Chem. 279 (8), 6834-6839 (2004)
Tanaka,M., et al. J. Biol. Chem. 279 (6), 4625-4631 (2004)
Nagano,Y., et al. J. Biol. Chem. 278 (51), 51504-51514 (2003)
Marx,F.P., etal. Hum. Mol. Genet. 12 (11), 1223-1231 (2003)
Junn,E., et al. J. Biol. Chem. 277 (49), 47870-47877 (2002)
Chung,K.K., et al. Nat. Med. 7 (10), 1144-1150 (2001)
Kawamata,H., et al. J. Neurochem. 77 (3), 929-934 (2001)
Engelender,S., et al. Nat. Genet. 22 (1), 110-114 (1999)
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