MeCP2 Polyclonal Antibody
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Application ![]()
| WB |
---|---|
Primary Accession | P51608 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 52441 Da |
Gene ID | 4204 |
---|---|
Other Names | Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) |
Dilution | WB~~WB: 1:2000 |
Format | PBS, pH 7.4, containing 0.09% (W/V) sodium azide as Preservative and 50% Glycerol. |
Storage Conditions | -20℃ |
Name | MECP2 |
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Function | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9Z2D6}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. |
Tissue Location | Present in all adult somatic tissues tested. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

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