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>   首页   >   产品   >   一抗   >   其他   >   Anti-CRHR1 Antibody   

Anti-CRHR1 Antibody

Rabbit polyclonal antibody to CRHR1

     
  • 1 - Anti-CRHR1 Antibody AP59991
    Western blot analysis of CRHR1 expression in HEK293T (A), Hela (B), DLD (C) whole cell lysates.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P34998
Other Accession P35347
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 47671 Da
Additional Information
Gene ID 1394
Other Names CRFR; CRFR1; CRHR; Corticotropin-releasing factor receptor 1; CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
Target/Specificity Recognizes endogenous levels of CRHR1 protein.
Dilution WB~~WB (1/500 - 1/1000)
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CRHR1 (HGNC:2357)
Function G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis
Tissue Location Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CRHR1. The exact sequence is proprietary.

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