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>   首页   >   产品   >   一抗   >   其他   >   Anti-Angiopoietin-2 Antibody   

Anti-Angiopoietin-2 Antibody

Rabbit polyclonal antibody to Angiopoietin-2

     
  • 1 - Anti-Angiopoietin-2 Antibody AP59912
    Western blot analysis of Angiopoietin-2 expression in mouse heart (A), mouse muscle (B) whole cell lysates.
  • 2 - Anti-Angiopoietin-2 Antibody AP59912
    Immunohistochemical analysis of Angiopoietin-2 staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary Accession O15123
Other Accession O35608
Reactivity Human, Mouse, Rat, Monkey, Pig, Drosophila
Host Rabbit
Clonality Polyclonal
Calculated MW 56919 Da
Additional Information
Gene ID 285
Other Names Angiopoietin-2; ANG-2
Target/Specificity Recognizes endogenous levels of Angiopoietin-2 protein.
Dilution WB~~WB (1/500 - 1/1000), IHC (1/50 - 1/200)
IHC~~WB (1/500 - 1/1000), IHC (1/50 - 1/200)
Format Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide.
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ANGPT2
Function Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Involved in the regulation of lymphangiogenesis (PubMed:32908006).
Cellular Location Secreted.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Angiopoietin-2. The exact sequence is proprietary.

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