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Thymosin beta 4 Rabbit pAb
Thymosin beta 4 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P62328 |
| Reactivity | Mouse |
| Predicted | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 5053 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Thymosin beta 4 |
| Epitope Specificity | 37-44/44 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. |
| SIMILARITY | Belongs to the thymosin beta family. |
| SUBUNIT | Interacts with SERPINB1. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Proteins in the thymosin beta family are highly conserved polar peptides that bind monomeric Actin and thereby inhibit Actin polymerization. These proteins act as the main intracellular G-Actin sequestering peptides. The most abundant thymosin beta family member in mammalian cells and tissues is thymosin beta-4 (Tbeta-4), also designated Seraspenide. T beta-4 participates in several cellular events including cancerogenesis, apoptosis, angiogenesis, blood coagulation and would healing. Specifically, T beta-4 promotes cell migration and adhesion, accelerates wound healing and reduces inflammation, and becomes upregulated in a wide variety of human carcinomas. Due to the effects of T beta-4 in these events, it may become a protein of significant biological and pharmaceutical relevance. |
| Gene ID | 7114 |
|---|---|
| Other Names | Thymosin beta-4, T beta-4, Fx, Hemoregulatory peptide AcSDKP, Ac-Ser-Asp-Lys-Pro, N-acetyl-SDKP, AcSDKP, Seraspenide, TMSB4X, TB4X, THYB4, TMSB4 |
| Target/Specificity | Originally found in thymus but it is widely distributed in many tissues. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | TMSB4X |
|---|---|
| Synonyms | TB4X, THYB4, TMSB4 |
| Function | Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398). |
| Cellular Location | Cytoplasm, cytoskeleton |
| Tissue Location | Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Proteins in the thymosin beta family are highly conserved polar peptides that bind monomeric Actin and thereby inhibit Actin polymerization. These proteins act as the main intracellular G-Actin sequestering peptides. The most abundant thymosin beta family member in mammalian cells and tissues is thymosin beta-4 (Tbeta-4), also designated Seraspenide. T beta-4 participates in several cellular events including cancerogenesis, apoptosis, angiogenesis, blood coagulation and would healing. Specifically, T beta-4 promotes cell migration and adhesion, accelerates wound healing and reduces inflammation, and becomes upregulated in a wide variety of human carcinomas. Due to the effects of T beta-4 in these events, it may become a protein of significant biological and pharmaceutical relevance.
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