癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KIR2DL2 Antibody (C-Term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, FC, E |
|---|---|
| Primary Accession | P43627 |
| Other Accession | P43626, NP_055034.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38472 Da |
| Antigen Region | 263-291 aa |
| Gene ID | 3803 |
|---|---|
| Other Names | Killer cell immunoglobulin-like receptor 2DL2, CD158 antigen-like family member B1, MHC class I NK cell receptor, Natural killer-associated transcript 6, NKAT-6, p58 natural killer cell receptor clone CL-43, p58 NK receptor CL-43, CD158b1, KIR2DL2, CD158B1, NKAT6 |
| Target/Specificity | This KIR2DL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human KIR2DL2. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KIR2DL2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KIR2DL2 (HGNC:6330) |
|---|---|
| Synonyms | CD158B1, NKAT6 |
| Function | Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
REFERENCES
Jiao, Y.L., et al. J. Clin. Immunol. 30(6):840-844(2010) Zhu, B.F., et al. Hum. Immunol. 71(11):1116-1123(2010) Gao, X., et al. Clin. Immunol. 137(1):139-146(2010) Al Omar, S., et al. Hum. Immunol. 71(10):976-981(2010) Velickovic, M., et al. Tissue Antigens (2010) In press :
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