癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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NPEPL1 Rabbit pAb
NPEPL1 Rabbit pAb
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q8NDH3 |
| Reactivity | Mouse |
| Predicted | Human, Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 55861 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NPEPL1 |
| Epitope Specificity | 371-470/494 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the peptidase M17 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Aminopeptidases are widely distributed in eukaryotes and prokaryotes. These enzymes catalyze the removal of amino acids from the N-termini of proteins or peptide substrates. Aminopeptidases are involved in regulating hormone levels and are essential for digestive and intracellular protein metabolism. NPEPL1, also referred to as aminopeptidase-like 1, is a 523 amino acid protein that belongs to the peptidase M17 family and is ubiquitously expressed. NPEPL1 may be involved in the processing, catabolism and degradation of intracellular proteins by catalyzing the removal of unsubstituted N-terminal amino acids from various peptides. NPEPL1 contains several zinc binding sites and and is expressed as three isoforms due to alternative splicing events. |
| Gene ID | 79716 |
|---|---|
| Other Names | Probable aminopeptidase NPEPL1, 3.4.11.-, Aminopeptidase-like 1, NPEPL1, KIAA1974 |
| Target/Specificity | Ubiquitously expressed. |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | NPEPL1 |
|---|---|
| Synonyms | KIAA1974 |
| Function | Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. |
| Tissue Location | Ubiquitously expressed. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Aminopeptidases are widely distributed in eukaryotes and prokaryotes. These enzymes catalyze the removal of amino acids from the N-termini of proteins or peptide substrates. Aminopeptidases are involved in regulating hormone levels and are essential for digestive and intracellular protein metabolism. NPEPL1, also referred to as aminopeptidase-like 1, is a 523 amino acid protein that belongs to the peptidase M17 family and is ubiquitously expressed. NPEPL1 may be involved in the processing, catabolism and degradation of intracellular proteins by catalyzing the removal of unsubstituted N-terminal amino acids from various peptides. NPEPL1 contains several zinc binding sites and and is expressed as three isoforms due to alternative splicing events.
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