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GRID2IP Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | A4D2P6 |
| Reactivity | Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 132276 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GRID2IP |
| Epitope Specificity | 921-1020/1121 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell junction > synapse > postsynaptic cell membrane. |
| SIMILARITY | Contains 1 FH2 (formin homology 2) domain. Contains 2 PDZ (DHR) domains. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Grid2ip is a postsynaptic scaffolding protein that contains one formin homology 2 (FH2) domain and two PDZ (postsynaptic density-95/discs-large/ZO-1) domains. Expressed in Purkinje cells of the cerebellum and localizing specifically to parallel fiber synapses, Grid2ip interacts with the C-terminus of GluR-Delta 2 and, via this interaction, links GluR-Delta 2 with various signaling molecules and the Actin cytoskeleton. GluR-Delta 2 is a glutamate receptor with an important role in motor learning, cerebellar wiring and synaptic plasticity. Due to alternative splicing events, three Grid2ip isoforms exist, namely L-delphilin, S-delphilin (or delphilin-Alpha) and delphilin-Beta. Each isoform exhibits individual expression patterns and protein interactions. Isoform 2, delphilin-Alpha, is palmytoylated, a modification that is essential for the enhanced expression of GluR-Delta 2 on the cell surface. This modification of delphilin-Alpha also mediates the accumulation of delphilin-Alpha in dendritic spines. |
| Gene ID | 392862 |
|---|---|
| Other Names | Delphilin, Glutamate receptor, ionotropic, delta 2-interacting protein 1, GRID2IP |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | GRID2IP |
|---|---|
| Function | Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. |
| Cellular Location | Postsynaptic cell membrane. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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