癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Keratin 18 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application 
| WB, ICC |
|---|---|
| Primary Accession | P05783 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Calculated MW | 48058 Da |
| Gene ID | 3875 |
|---|---|
| Other Names | Cell proliferation inducing gene 46 protein;Cell proliferation inducing protein 46;Cell proliferation-inducing gene 46 protein;CK 18;CK-18;CK18;Cytokeratin 18;Cytokeratin endo B;Cytokeratin-18;Cytokeratin18;K 18;K18;K1C18_HUMAN;Keratin 18;Keratin D;Keratin type I cytoskeletal 18;keratin, type I cytoskeletal 18;Keratin-18;Keratin18;Kerd;KRT18. |
| Dilution | WB~~1:2000 ICC~~1:800 |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | KRT18 |
|---|---|
| Synonyms | CYK18 |
| Function | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Cellular Location | Nucleus matrix {ECO:0000250|UniProtKB:Q5BJY9}. Cytoplasm, perinuclear region. Nucleus, nucleolus. Cytoplasm {ECO:0000250|UniProtKB:Q5BJY9} |
| Tissue Location | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
REFERENCES
Oshima R.G.,et al.Differentiation 33:61-68(1986).
Kim J.W.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kulesh D.A.,et al.Mol. Cell. Biol. 8:1540-1550(1988).
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