癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MYOZ1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q9NP98 |
| Other Accession | Q4PS85, Q9JK37 |
| Reactivity | Human, Mouse |
| Predicted | Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31745 Da |
| Antigen Region | 40-69 aa |
| Gene ID | 58529 |
|---|---|
| Other Names | Myozenin-1, Calsarcin-2, Filamin-, actinin- and telethonin-binding protein, Protein FATZ, MYOZ1 (HGNC:13752) |
| Target/Specificity | This MYOZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the Central region of human MYOZ1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MYOZ1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYOZ1 (HGNC:13752) |
|---|---|
| Function | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Cellular Location | Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle |
| Tissue Location | Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. This protein plays an important role in the modulation of calcineurin signaling, may play a role in myofibrillogenesis.
REFERENCES
Aurino, S., et al. Acta Myol 27, 90-97 (2008) Posch, M.G., et al. Mol. Genet. Metab. 91(2):207-208(2007) Arola, A.M., et al. Mol. Genet. Metab. 90(4):435-440(2007)
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