癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CD158g Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q14953 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33698 Da |
| Gene ID | 3810 |
|---|---|
| Other Names | Killer cell immunoglobulin-like receptor 2DS5, CD158 antigen-like family member G, MHC class I NK cell receptor, Natural killer-associated transcript 9, NKAT-9, CD158g, KIR2DS5, CD158G, NKAT9 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD158g. The exact sequence is proprietary. |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | KIR2DS5 {ECO:0000303|PubMed:18624290, ECO:0000312|HGNC:HGNC:6337} |
|---|---|
| Function | Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:18624290, PubMed:18682925, PubMed:28685972). Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 represented in this entry (PubMed:28685972). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein; Extracellular side |
| Tissue Location | Expressed on a discrete subset of peripheral blood NK cells. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
REFERENCES
Doehring C.,et al.Immunogenetics 44:227-230(1996).
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