癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCNT1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q5JUK3 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 138343 Da |
| Gene ID | 57582 |
|---|---|
| Other Names | Potassium channel subfamily T member 1, KCa41, KCNT1, KIAA1422 |
| Dilution | WB~~ 1:1000 IHC~~1:50-100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | KCNT1 (HGNC:18865) |
|---|---|
| Function | Sodium-activated K(+) channel (PubMed:37494189). Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity). Regulates neuronal bursting in sensory neurons (By similarity). Contributes to synaptic development and plasticity (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9Z258}; Multi-pass membrane protein |
| Tissue Location | Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).
REFERENCES
Humphray S.J.,et al.Nature 429:369-374(2004).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Heron S.E.,et al.Nat. Genet. 44:1188-1190(2012).
Barcia G.,et al.Nat. Genet. 44:1255-1259(2012).
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