Thrombin Receptor Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB |
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Primary Accession | P25116 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Calculated MW | 47441 Da |
Gene ID | 2149 |
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Other Names | Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor, F2R, CF2R, PAR1, TR |
Dilution | WB~~1:500- 1:1000 |
Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
Storage Conditions | -20℃ |
Name | F2R (HGNC:3537) |
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Synonyms | CF2R, PAR1, TR |
Function | High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L- glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (PubMed:10079109). Mediates up- regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (PubMed:30568593, PubMed:34831181). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P26824}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P26824} |
Tissue Location | Platelets and vascular endothelial cells. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
REFERENCES
Vu T.-K.H.,et al.Cell 64:1057-1068(1991).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shapiro M.J.,et al.J. Biol. Chem. 271:32874-32880(1996).
Kahn M.L.,et al.J. Clin. Invest. 103:879-887(1999).
Zania P.,et al.J. Pharmacol. Exp. Ther. 328:378-389(2009).

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