mGluR6 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IHC |
---|---|
Primary Accession | O15303 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Calculated MW | 95468 Da |
Gene ID | 2916 |
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Other Names | Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6 |
Dilution | WB~~ 1:1000 IHC~~1:50-1:100 |
Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
Storage Conditions | -20℃ |
Name | GRM6 |
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Synonyms | GPRC1F, MGLUR6 |
Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane |
Tissue Location | Detected in melanocytes. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
REFERENCES
Hashimoto T.,et al.Eur. J. Neurosci. 9:1226-1235(1997).
Schmutz J.,et al.Nature 431:268-274(2004).
Devi S.,et al.Pigment Cell Melanoma Res. 26:348-356(2013).
Dryja T.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:4884-4889(2005).
Sjoeblom T.,et al.Science 314:268-274(2006).

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