癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCNG3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8TAE7 |
| Other Accession | Q8R523, P59053 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49593 Da |
| Antigen Region | 6-34 aa |
| Gene ID | 170850 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily G member 3, Voltage-gated potassium channel subunit Kv101, Voltage-gated potassium channel subunit Kv63, KCNG3 |
| Target/Specificity | This KCNG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human KCNG3. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNG3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNG3 (HGNC:18306) |
|---|---|
| Function | Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the inactivation and deactivation rate (PubMed:11852086, PubMed:12060745, PubMed:19074135). Potassium channel subunit that does not form functional channels by itself (PubMed:11852086, PubMed:12060745). Reduces the deactivation rate (PubMed:11852086). Moderately accelerates activation (PubMed:12060745). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135). Retains in the endoplasmic reticulum in the absence of KCNB1 (PubMed:12060745) |
| Tissue Location | Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed:11852086, PubMed:12060745). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule.
REFERENCES
Mederos Y Schnitzler, M., et al. J. Biol. Chem. 284(7):4695-4704(2009)
Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)
Vega-Saenz de Miera, E.C. Brain Res. Mol. Brain Res. 123 (1-2), 91-103 (2004)
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