癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OPN1MW Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| FC, WB, E |
|---|---|
| Primary Accession | P04001 |
| Other Accession | O12948, P04000, P22329, O35476 |
| Reactivity | Human |
| Predicted | Rat, Chicken, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40584 Da |
| Antigen Region | 21-50 aa |
| Gene ID | 101060233;2652 |
|---|---|
| Other Names | Medium-wave-sensitive opsin 1, Green cone photoreceptor pigment, Green-sensitive opsin, GOP, OPN1MW, GCP |
| Target/Specificity | This OPN1MW antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human OPN1MW. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OPN1MW Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OPN1MW (HGNC:4206) |
|---|---|
| Synonyms | GCP |
| Function | Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | The three color pigments are found in the cone photoreceptor cells. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
OPN1MW encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness.
REFERENCES
Thirumuruganandham, S.P., et al. J Mol Model 15(8):959-969(2009)
Ala-Laurila, P., et al. J. Biol. Chem. 284(24):16492-16500(2009)
Holmes, M.V., et al. PLoS ONE 4 (12), E7960 (2009)
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