癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC14A2 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P-Leica, E |
|---|---|
| Primary Accession | Q15849 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101209 Da |
| Gene ID | 8170 |
|---|---|
| Other Names | Urea transporter 2, Solute carrier family 14 member 2, Urea transporter, kidney, SLC14A2, HUT2, UT2 |
| Target/Specificity | This SLC14A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 42-76 amino acids from the human region of human SLC14A2. |
| Dilution | WB~~1:500 IHC-P-Leica~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC14A2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC14A2 |
|---|---|
| Synonyms | HUT2, UT2 |
| Function | [Isoform 1]: Mediates the transport of urea driven by a concentration gradient across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. |
| Cellular Location | [Isoform 1]: Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | [Isoform 1]: Epressed in the inner medulla of the kidney (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism.
REFERENCES
Olives B.,et al.FEBS Lett. 386:156-160(1996).
Bagnasco S.M.,et al.Am. J. Physiol. 281:F400-F406(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mistry A.C.,et al.J. Biol. Chem. 282:30097-30106(2007).
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