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>   首页   >   产品   >   一抗   >   精选抗体   >   LLGL2 Antibody (C-term)   

LLGL2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - LLGL2 Antibody (C-term) AP2199a
    Western blot analysis of LLGL2 antibody (C-term) (Cat. #AP2199a) in K562 cell line lysates (35ug/lane). LLGL2 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q6P1M3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 113448 Da
Antigen Region 940-973 aa
Additional Information
Gene ID 3993
Other Names Lethal(2) giant larvae protein homolog 2, HGL, LLGL2
Target/Specificity This LLGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-973 amino acids from the C-terminal region of human LLGL2.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLLGL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LLGL2
Function Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par- 6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
Cellular Location Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell- cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.

REFERENCES

Yasumi, M., et al., J. Biol. Chem. 280(8):6761-6765 (2005). Katoh, M., et al., Int. J. Oncol. 24(3):737-742 (2004).

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