癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AKR7A3 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O95154 |
| Other Accession | Q8NHP1 |
| Reactivity | Human, Rat |
| Predicted | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37206 Da |
| Gene ID | 22977 |
|---|---|
| Other Names | Aflatoxin B1 aldehyde reductase member 3, 1.-.-.-, AFB1 aldehyde reductase 2, AFB1-AR 2, AKR7A3, AFAR2 |
| Target/Specificity | This AKR7A3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 33-64 amino acids from the human region of human AKR7A3. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AKR7A3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AKR7A3 (HGNC:390) |
|---|---|
| Function | Catalyzes the NADPH-dependent reduction of various carbonyl- containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P38918}. |
| Tissue Location | Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
REFERENCES
Knight L.P.,et al.Carcinogenesis 20:1215-1223(1999).
Praml C.,et al.Oncogene 22:4765-4773(2003).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bodreddigari S.,et al.Chem. Res. Toxicol. 21:1134-1142(2008).
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