癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TRIM55 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BYV6 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60466 Da |
| Gene ID | 84675 |
|---|---|
| Other Names | Tripartite motif-containing protein 55, Muscle-specific RING finger protein 2, MuRF-2, MuRF2, RING finger protein 29, TRIM55, MURF2, RNF29 |
| Target/Specificity | This TRIM55 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 216-250 amino acids from the Central region of human TRIM55. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM55 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM55 |
|---|---|
| Synonyms | MURF2, RNF29 |
| Function | E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression (By similarity). Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF- kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Also modifies PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity (PubMed:36737649). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:G3X8Y1}. Cytoplasm {ECO:0000250|UniProtKB:G3X8Y1}. Note=TLR4 signaling pathway promotes nuclear translocation. {ECO:0000250|UniProtKB:G3X8Y1} |
| Tissue Location | Highly expressed in muscle. Low-level expression in liver. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May regulate gene expression and protein turnover in muscle cells.
REFERENCES
Centner T.,et al.J. Mol. Biol. 306:717-726(2001).
Pizon V.,et al.J. Cell Sci. 115:4469-4482(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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Cat# AP21736c
