癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
(DANRE) gpr126 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | C6KFA3 |
| Reactivity | Zebrafish |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 130813 Da |
| Gene ID | 561970 |
|---|---|
| Other Names | G-protein coupled receptor 126, gpr126 |
| Target/Specificity | This DANRE gpr126 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1135-1169 amino acids from the C-terminal region of DANRE gpr126. |
| Dilution | WB~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (DANRE) gpr126 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | adgrg6 |
|---|---|
| Synonyms | gpr126 {ECO:0000303|PubMed:19745155} |
| Function | Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). Adgrg6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:25118328). Also able to couple to G(q) G proteins (PubMed:25118328). Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155, PubMed:23804499, PubMed:25118328, PubMed:25695270, PubMed:31924782). G-protein coupled receptor activity can also be activated by type IV collagen, a major constituent of the basement membrane (PubMed:25118328). Also plays a role inner ear development (PubMed:24067352). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in Schwann cells of the posterior lateral line nerve and in brain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Orphan receptor. Required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Required for normal expression of the transcription factors oct6 and krox20 that are required for Schwann cells to inititate myelination.
REFERENCES
Monk K.R.,et al.Science 325:1402-1405(2009).
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