HCRTR1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application ![]()
| WB, E |
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Primary Accession | O43613 |
Reactivity | Human, Rat, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47536 Da |
Gene ID | 3061 |
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Other Names | Orexin receptor type 1, Ox-1-R, Ox1-R, Ox1R, Hypocretin receptor type 1, HCRTR1 |
Target/Specificity | This HCRTR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 256-291 amino acids from the Central region of human HCRTR1. |
Dilution | WB~~1:500-1:1000 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HCRTR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HCRTR1 (HGNC:4848) |
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Function | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:26950369, PubMed:9491897). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:26950369, PubMed:9491897). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
REFERENCES
Sakurai T.,et al.Cell 92:573-585(1998).
Peyron C.,et al.Nat. Med. 6:991-997(2000).
Olafsdottir B.R.,et al.Neurology 57:1896-1899(2001).
Yeager M.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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