癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MYL12B Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O14950 |
| Other Accession | P18666, Q3THE2, NP_001138416.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19779 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 103910 |
|---|---|
| Other Names | Myosin regulatory light chain 12B, MLC-2A, MLC-2, Myosin regulatory light chain 2-B, smooth muscle isoform, Myosin regulatory light chain 20 kDa, MLC20, Myosin regulatory light chain MRLC2, SHUJUN-1, MYL12B, MRLC2, MYLC2B |
| Target/Specificity | This MYL12B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MYL12B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MYL12B Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYL12B |
|---|---|
| Synonyms | MRLC2, MYLC2B |
| Function | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. |
| Tissue Location | Ubiquitously expressed in various hematopoietic cells. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).
REFERENCES
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
Umeda, D., et al. Biochem. Biophys. Res. Commun. 333(2):628-635(2005)
Li, T.B., et al. Acta Biochim. Biophys. Sin. (Shanghai) 36(6):412-418(2004)
Webb, R.C. Adv Physiol Educ 27 (1-4), 201-206 (2003) :
Iwasaki, T., et al. Cell Struct. Funct. 26(6):677-683(2001)
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