癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RECQL4 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O94761 |
| Other Accession | NP_004251.3 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 133067 Da |
| Antigen Region | 1134-1162 aa |
| Gene ID | 9401 |
|---|---|
| Other Names | ATP-dependent DNA helicase Q4, DNA helicase, RecQ-like type 4, RecQ4, RTS, RecQ protein-like 4, RECQL4, RECQ4 |
| Target/Specificity | This RECQL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1134-1162 amino acids from the C-terminal region of human RECQL4. |
| Dilution | IHC-P~~1:100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RECQL4 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RECQL4 |
|---|---|
| Synonyms | RECQ4 {ECO:0000303|PubMed:9878247} |
| Function | An ATP-dependent DNA helicase which unwinds dsDNA with a 3'- overhang in a 3'-5' direction (PubMed:28653661). Does not unwind more than 18 bp of dsDNA (PubMed:28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed:22730300). The core helicase domain binds ssDNA (PubMed:22730300, PubMed:28653661). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Ubiquitously expressed, with highest levels in thymus and testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq].
REFERENCES
Rossi, M.L., et al. DNA Repair (Amst.) 9(7):796-804(2010)
Singh, D.K., et al. Aging Cell 9(3):358-371(2010)
Thangavel, S., et al. Mol. Cell. Biol. 30(6):1382-1396(2010)
Xu, X., et al. EMBO J. 28(19):3005-3014(2009)
Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15628-15632(2009)
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