癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRKCSH Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P14314 |
| Other Accession | Q28034, NP_002734.2 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59425 Da |
| Antigen Region | 6-35 aa |
| Gene ID | 5589 |
|---|---|
| Other Names | Glucosidase 2 subunit beta, 80K-H protein, Glucosidase II subunit beta, Protein kinase C substrate 601 kDa protein heavy chain, PKCSH, PRKCSH, G19P1 |
| Target/Specificity | This PRKCSH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human PRKCSH. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRKCSH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRKCSH {ECO:0000303|PubMed:28375157, ECO:0000312|HGNC:HGNC:9411} |
|---|---|
| Function | Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). |
| Cellular Location | Endoplasmic reticulum {ECO:0000255|PROSITE- ProRule:PRU10138, ECO:0000305|PubMed:10929008} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum (ER). This protein is an acidic phospho-protein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease (PCLD). Alternatively spliced transcript variants encoding distinct isoforms have been observed.
REFERENCES
Hoverfelt, A., et al. Diabetologia 53(9):1903-1907(2010)
Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)
van Keimpema, L., et al. Liver Int. (2010) In press :
Yang, A.M., et al. Dig. Dis. Sci. 55(3):815-819(2010)
Gao, H., et al. Hum. Mol. Genet. 19(1):16-24(2010)
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