癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GNB4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HAV0 |
| Other Accession | O35353, P29387, P79959, P54311, P62874, P62873, P26308, Q6PH57, Q6TMK6, P62871, NP_067642.1 |
| Reactivity | Human |
| Predicted | Bovine, Hamster, Zebrafish, Drosophila, Mouse, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37567 Da |
| Antigen Region | 109-138 aa |
| Gene ID | 59345 |
|---|---|
| Other Names | Guanine nucleotide-binding protein subunit beta-4, Transducin beta chain 4, GNB4 |
| Target/Specificity | This GNB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the Central region of human GNB4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNB4 |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Tissue Location | Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.
REFERENCES
Riemann, K., et al. Anticancer Res. 29(4):1271-1274(2009)
Riemann, K., et al. Pharmacogenet. Genomics 18(11):999-1008(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Rosskopf, D., et al. FEBS Lett. 544 (1-3), 27-32 (2003) :
Jiang, G., et al. Am. J. Physiol. Endocrinol. Metab. 284 (4), E671-E678 (2003) :
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