癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PTGFRN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P2B2 |
| Other Accession | NP_065173.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 98556 Da |
| Antigen Region | 458-485 aa |
| Gene ID | 5738 |
|---|---|
| Other Names | Prostaglandin F2 receptor negative regulator, CD9 partner 1, CD9P-1, Glu-Trp-Ile EWI motif-containing protein F, EWI-F, Prostaglandin F2-alpha receptor regulatory protein, Prostaglandin F2-alpha receptor-associated protein, CD315, PTGFRN, CD9P1, EWIF, FPRP, KIAA1436 |
| Target/Specificity | This PTGFRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-485 amino acids from the Central region of human PTGFRN. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTGFRN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTGFRN |
|---|---|
| Synonyms | CD9P1, EWIF, FPRP, KIAA1436 |
| Function | Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PTGFRN inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).
REFERENCES
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)
Andre, M., et al. J Proteomics 73(1):93-102(2009)
Andre, M., et al. Proteomics 7(21):3880-3895(2007)
Abache, T., et al. J. Cell. Biochem. 102(3):650-664(2007)
Sala-Valdes, M., et al. J. Biol. Chem. 281(28):19665-19675(2006)
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