癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EXTL1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q92935 |
| Other Accession | Q9JKV7, NP_004446.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74697 Da |
| Antigen Region | 649-676 aa |
| Gene ID | 2134 |
|---|---|
| Other Names | Exostosin-like 1, Exostosin-L, Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostosis-like protein, EXTL1, EXTL |
| Target/Specificity | This EXTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 649-676 amino acids from the C-terminal region of human EXTL1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EXTL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EXTL1 |
|---|---|
| Synonyms | EXTL |
| Function | Glycosyltransferase required for the biosynthesis of heparan- sulfate (HS) (PubMed:11390981). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity) (PubMed:11390981). Appears to lack GlcNAcT I and GlcAT-II activities (PubMed:11390981). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin.
REFERENCES
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Mathysen, D., et al. Eur. J. Cancer 40(8):1255-1261(2004)
Zak, B.M., et al. Biochim. Biophys. Acta 1573(3):346-355(2002)
Kim, B.T., et al. Proc. Natl. Acad. Sci. U.S.A. 98(13):7176-7181(2001)
Xu, L., et al. Hum. Genet. 105 (1-2), 45-50 (1999) :
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