癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CNTNAP4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9C0A0 |
| Other Accession | NP_207837.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 145274 Da |
| Antigen Region | 1204-1231 aa |
| Gene ID | 85445 |
|---|---|
| Other Names | Contactin-associated protein-like 4, Cell recognition molecule Caspr4, CNTNAP4, CASPR4, KIAA1763 |
| Target/Specificity | This CNTNAP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1204-1231 amino acids from the C-terminal region of human CNTNAP4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNTNAP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNTNAP4 |
|---|---|
| Synonyms | CASPR4, KIAA1763 |
| Function | Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system (By similarity). |
| Cellular Location | Presynaptic cell membrane {ECO:0000250|UniProtKB:Q99P47}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q99P47}. Note=Specifically present within the presynaptic compartment of synapses. {ECO:0000250|UniProtKB:Q99P47} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :
Nordgard, S.H., et al. Genes Chromosomes Cancer 47(8):680-696(2008)
Kim, J.M., et al. DNA Res. 13(6):275-286(2006)
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