癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NKX6-1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P78426 |
| Other Accession | O35762, Q99MA9, NP_006159.2 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37849 Da |
| Antigen Region | 6-1 aa |
| Gene ID | 4825 |
|---|---|
| Other Names | Homeobox protein Nkx-61, Homeobox protein NK-6 homolog A, NKX6-1, NKX6A |
| Target/Specificity | This NKX6-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human NKX6-1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NKX6-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKX6-1 |
|---|---|
| Synonyms | NKX6A |
| Function | Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Pancreatic beta cells. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM].
REFERENCES
Donelan, W., et al. J. Biol. Chem. 285(16):12181-12189(2010)
Zhu, S., et al. Dig. Dis. Sci. 54(5):996-1002(2009)
Schisler, J.C., et al. Mol. Cell. Biol. 28(10):3465-3476(2008)
Yokoi, N., et al. Diabetes 55(8):2379-2386(2006)
Hori, Y., et al. PLoS Med. 2 (4), E103 (2005) :
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