癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FHOD1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y613 |
| Other Accession | NP_037373.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 126551 Da |
| Antigen Region | 985-1013 aa |
| Gene ID | 29109 |
|---|---|
| Other Names | FH1/FH2 domain-containing protein 1, Formin homolog overexpressed in spleen 1, FHOS, Formin homology 2 domain-containing protein 1, FHOD1, FHOS, FHOS1 |
| Target/Specificity | This FHOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 985-1013 amino acids from the C-terminal region of human FHOD1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FHOD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FHOD1 |
|---|---|
| Synonyms | FHOS, FHOS1 |
| Function | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic |
| Tissue Location | Ubiquitous. Highly expressed in spleen. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq].
REFERENCES
Hannemann, S., et al. J. Biol. Chem. 283(41):27891-27903(2008)
Schulte, A., et al. Structure 16(9):1313-1323(2008)
Takeya, R., et al. EMBO J. 27(4):618-628(2008)
Schulte, A., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (PT 10), 878-881 (2007) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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