癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
P2RX2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UBL9 |
| Other Accession | NP_057402.1, NP_777362.1, NP_733783.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51754 Da |
| Antigen Region | 81-109 aa |
| Gene ID | 22953 |
|---|---|
| Other Names | P2X purinoceptor 2, P2X2, ATP receptor, Purinergic receptor, P2RX2, P2X2 |
| Target/Specificity | This P2RX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the N-terminal region of human P2RX2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P2RX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RX2 (HGNC:15459) |
|---|---|
| Synonyms | P2X2 |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Localizes to the apical membranes of hair cells in the organ of Corti. |
| Tissue Location | Expressed in both the central and peripheral nervous system, as well as in the pituitary gland |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.
REFERENCES
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)
Decker, D.A., et al. Neurogastroenterol. Motil. 22(8):901-908(2010)
Coddou, C., et al. J. Neurosci. 29(39):12284-12291(2009)
Pannek, J., et al. Spinal Cord 47(7):561-564(2009)
Chaumont, S., et al. Sci Signal 1 (41), RA8 (2008) :
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