癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PFN2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P35080 |
| Other Accession | Q9EPC6, Q9JJV2, Q4R4P8, Q09430, NP_444252.1, NP_002619.1 |
| Reactivity | Human |
| Predicted | Bovine, Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15046 Da |
| Antigen Region | 110-139 aa |
| Gene ID | 5217 |
|---|---|
| Other Names | Profilin-2, Profilin II, PFN2 |
| Target/Specificity | This PFN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-139 amino acids from the C-terminal region of human PFN2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PFN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PFN2 |
|---|---|
| Function | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. |
| Cellular Location | Cytoplasm, cytoskeleton. |
| Tissue Location | Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.
REFERENCES
Shao, J., et al. Mol. Cell. Biol. 28(17):5196-5208(2008)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Xu, J., et al. Cell. Signal. 19(7):1575-1582(2007)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Lederer, M., et al. J. Cell. Sci. 118 (PT 2), 331-341 (2005) :
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李
2017-07-07 14:20:28
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Species tested
大鼠
Application tested
260MA湿转30min 1:700一抗 4°过夜 1:1000碧云天二抗过夜
Organization tested
大鼠海马组织 IP细胞裂解液 裂解
Barcode encoding
Brief protocol
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