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>   首页   >   产品   >   一抗   >   心血管   >   A2M Antibody (C-term)   

A2M Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - A2M Antibody (C-term) AP14790b
    A2M Antibody (C-term) (Cat. #AP14790b) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the A2M antibody detected the A2M protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01023
Other Accession NP_000005.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 163291 Da
Antigen Region 1162-1192 aa
Additional Information
Gene ID 2
Other Names Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5
Target/Specificity This A2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1162-1192 amino acids from the C-terminal region of human A2M.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsA2M Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name A2M
Synonyms CPAMD5
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Cellular Location Secreted.
Tissue Location Secreted in plasma..
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq].

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bruno, E., et al. Neurosci. Lett. 482(2):112-116(2010)
Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Song, H., et al. Neurosci. Lett. 479(2):143-145(2010)
Seriramalu, R., et al. Electrophoresis 31(14):2388-2395(2010)

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