癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
YY2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O15391 |
| Other Accession | NP_996806.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41347 Da |
| Antigen Region | 224-253 aa |
| Gene ID | 404281 |
|---|---|
| Other Names | Transcription factor YY2, Yin and yang 2, YY-2, Zinc finger protein 631, YY2, ZNF631 |
| Target/Specificity | This YY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-253 amino acids from the C-terminal region of human YY2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | YY2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | YY2 |
|---|---|
| Synonyms | ZNF631 |
| Function | Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in kidney, liver, spleen and testis but not in colon. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14.
REFERENCES
Chen, L., et al. Nucleic Acids Res. 38(12):4011-4026(2010)
Klar, M., et al. Gene 430 (1-2), 58-63 (2009) :
Kim, J.D., et al. Nucleic Acids Res. 35(10):3442-3452(2007)
Luo, C., et al. Genomics 87(3):348-355(2006)
Klar, M., et al. Mol. Cell. Biol. 25(22):10159-10170(2005)
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