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ADSS Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ADSS Antibody (C-term) AP13092b
    ADSS Antibody (C-term) (Cat. #AP13092b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ADSS antibody detected the ADSS protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P30520
Other Accession NP_001117.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 50097 Da
Antigen Region 396-422 aa
Additional Information
Gene ID 159
Other Names Adenylosuccinate synthetase isozyme 2 {ECO:0000255|HAMAP-Rule:MF_03127}, AMPSase 2 {ECO:0000255|HAMAP-Rule:MF_03127}, AdSS 2 {ECO:0000255|HAMAP-Rule:MF_03127}, 6344 {ECO:0000255|HAMAP-Rule:MF_03127}, Adenylosuccinate synthetase, acidic isozyme {ECO:0000255|HAMAP-Rule:MF_03127}, Adenylosuccinate synthetase, liver isozyme {ECO:0000255|HAMAP-Rule:MF_03127}, L-type adenylosuccinate synthetase {ECO:0000255|HAMAP-Rule:MF_03127}, IMP--aspartate ligase 2 {ECO:0000255|HAMAP-Rule:MF_03127}, ADSS {ECO:0000255|HAMAP-Rule:MF_03127}
Target/Specificity This ADSS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-422 amino acids from the C-terminal region of human ADSS.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADSS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADSS2 (HGNC:292)
Function Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03127}. Mitochondrion {ECO:0000250|UniProtKB:A4Z6H1}. Note=Partially associated with particulate fractions
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.

REFERENCES

Sivendran, S., et al. Protein Sci. 17(7):1162-1174(2008)
Zhang, F., et al. BMC Med. Genet. 9, 119 (2008) :
Zhang, F., et al. Behav Brain Funct 4, 39 (2008) :
Sun, H., et al. Mol. Cell. Biochem. 269 (1-2), 85-94 (2005) :
Stepinski, J., et al. Kidney Int. 50(4):1195-1201(1996)

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