癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ELAVL2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, WB, FC, E |
|---|---|
| Primary Accession | Q12926 |
| Other Accession | Q7SZT7, O09032, Q61701, P26378, Q91584, Q60900, Q14576, Q91903, Q8CH84, Q60899, NP_001164666.1, NP_001164668.1 |
| Reactivity | Human, Mouse |
| Predicted | Mouse, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39504 Da |
| Antigen Region | 156-184 aa |
| Gene ID | 1993 |
|---|---|
| Other Names | ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B, HuB, Nervous system-specific RNA-binding protein Hel-N1, ELAVL2, HUB |
| Target/Specificity | This ELAVL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the Central region of human ELAVL2. |
| Dilution | IHC-P~~1:100 WB~~1:2000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ELAVL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ELAVL2 |
|---|---|
| Synonyms | HUB |
| Function | RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity). |
| Tissue Location | Brain; neural-specific. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene.
REFERENCES
Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
D'Alessandro, V., et al. Cell. Oncol. 30(4):291-297(2008)
Jonson, L., et al. Mol. Cell Proteomics 6(5):798-811(2007)
Yano, M., et al. J. Biol. Chem. 280(13):12690-12699(2005)
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