癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DULLARD Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | O95476 |
| Other Accession | Q3B7T6, Q3TP92, Q1RMV9, NP_001137247.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28377 Da |
| Antigen Region | 131-160 aa |
| Gene ID | 23399 |
|---|---|
| Other Names | CTD nuclear envelope phosphatase 1, Serine/threonine-protein phosphatase dullard, CTDNEP1, DULLARD |
| Target/Specificity | This DULLARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the Central region of human DULLARD. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DULLARD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTDNEP1 |
|---|---|
| Synonyms | DULLARD |
| Function | Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein |
| Tissue Location | Muscle specific with lower expression in other metabolic tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Serine/threonine phosphatase which may be required for proper nuclear membrane morphology. Involved in LPIN1 dephosphorylation. May antagonize BMP signaling.
REFERENCES
Kim, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 104(16):6596-6601(2007)
Zhang, Y., et al. Mol. Cell 24(5):759-770(2006)
Satow, R., et al. Dev. Cell 11(6):763-774(2006)
Satow, R., et al. Biochem. Biophys. Res. Commun. 295(1):85-91(2002)
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