癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC30A7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8NEW0 |
| Other Accession | Q5BJM8, Q9JKN1, A4IFD7, Q6NRI1, Q52KD7, NP_598003.2, NP_001138356.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Xenopus, Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41626 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 148867 |
|---|---|
| Other Names | Zinc transporter 7, ZnT-7, Solute carrier family 30 member 7, Znt-like transporter 2, SLC30A7, ZNT7, ZNTL2 |
| Target/Specificity | This SLC30A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC30A7. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC30A7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC30A7 (HGNC:19306) |
|---|---|
| Function | Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:15525635, PubMed:15994300). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed:15525635, PubMed:15994300). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9JKN1} Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9JKN1} Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q5BJM8}. Mitochondrion {ECO:0000250|UniProtKB:Q5BJM8} |
| Tissue Location | Highly expressed in megakaryocytes and other bone marrow cells and in the epithelium of the small intestine. Expressed in testis (in Leydig cells), adrenal gland (in adrenal medula, zona fasciculata and zona of reticularis), and pituitary gland (in somatotropic cells). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).
REFERENCES
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
Zhang, L.H., et al. Brain Res. Bull. 77(1):55-60(2008)
Overbeck, S., et al. J. Leukoc. Biol. 83(2):368-380(2008)
Falcon-Perez, J.M., et al. Exp. Cell Res. 313(7):1473-1483(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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