癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DTNA Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IF, WB, E |
|---|---|
| Primary Accession | Q9Y4J8 |
| Other Accession | NP_116760.2, NP_001383.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 83901 Da |
| Antigen Region | 692-721 aa |
| Gene ID | 1837 |
|---|---|
| Other Names | Dystrobrevin alpha, DTN-A, Alpha-dystrobrevin, Dystrophin-related protein 3, DTNA, DRP3 |
| Target/Specificity | This DTNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human DTNA. |
| Dilution | IHC-P~~1:100~500 IF~~1:10~50 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DTNA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DTNA (HGNC:3057) |
|---|---|
| Synonyms | DRP3 |
| Function | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Cellular Location | Cytoplasm. Synapse. Cell membrane. Note=In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane. |
| Tissue Location | Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Bohm, S.V., et al. BMC Biol. 7, 85 (2009) :
Nakamori, M., et al. Neurology 70(9):677-685(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Lim, J., et al. Cell 125(4):801-814(2006)
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