癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CACNG8 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8WXS5 |
| Other Accession | Q8VHW5, Q8VHW2, NP_114101.4 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43313 Da |
| Antigen Region | 90-119 aa |
| Gene ID | 59283 |
|---|---|
| Other Names | Voltage-dependent calcium channel gamma-8 subunit, Neuronal voltage-gated calcium channel gamma-8 subunit, Transmembrane AMPAR regulatory protein gamma-8, TARP gamma-8, CACNG8, CACNG6 |
| Target/Specificity | This CACNG8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the N-terminal region of human CACNG8. |
| Dilution | WB~~1:500 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CACNG8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CACNG8 (HGNC:13628) |
|---|---|
| Synonyms | CACNG6 |
| Function | Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8VHW2}; Multi-pass membrane protein. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8VHW2} |
| Tissue Location | Detected in heart left ventricle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon.
REFERENCES
Sager, C., et al. Neuroscience 158(1):45-54(2009)
Correia, S.S., et al. Nat. Neurosci. 11(4):457-466(2008)
Chen, R.S., et al. Cell Biochem. Biophys. 47(2):178-186(2007)
Chu, P.J., et al. Gene 280 (1-2), 37-48 (2001) :
Burgess, D.L., et al. Genomics 71(3):339-350(2001)
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